Of course, Wyle is no stranger to garnering awards buzz, having earned 5 noms for Outstanding Supporting Actor in a Drama for his excellent work as up-and-coming surgeon Dr. John Carter on ER. On his newest series,

In a statement shared with PEOPLE, Wyle, 54, said of the nominations, including one for outstanding lead actor in a drama series, "I’m humbled and grateful"

Seth Rogen, Stephen Graham, Noah Wyle, Katherina LaNasa and more reacted to their Emmy nominations, which were announced Tuesday morning.