Recently, scientists at SIMM determined the crystal structure of GCGR in complex with a glucagon analogue and partial agonist NNC1702. This structure reveals, for the first time, the molecular ...

Chemists discover structure of glucagon fibrils Study may be a step toward shelf-stable versions of the hormone, which is used ... which appears in Nature Structural and Molecular Biology.

Chemists discover structure of glucagon fibrils Date: June 24, 2019 Source: Massachusetts Institute of Technology Summary: Study may be a step toward shelf-stable versions of the hormone, which is ...

Class B G protein-coupled receptors (GPCRs) exert essential action in hormonal homeostasis and are important therapeutic targets for a variety of diseases including metabolic disorders such as ...

Glucagon Receptor Structure Offers New Opportunities for Type 2 Diabetes Drug Discovery. PUBLISHED ON January 04, 2018 10:23 AM - Complex structure of a class B GPCR bound to an analogue of its ...

Molecular dynamics (MD) ... Underwood, C. R. et al. Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor. J.