Because of its alpha-cell nature and the presence of clinical diabetes, portions of the tumor were assayed for glucagon by the specific radioactive immunoassay previously described by Unger et al ...

MIT researchers have developed an implant that releases glucagol under the control of external sensors to protect diabetes ...

Most treatments for diabetes focus on insulin, but its counterpart -- the hormone glucagon that is produced by alpha cells in the pancreas -- has received comparatively little attention, says ...

Beta cells play a key role in the pathogenesis of both Type 1 and Type 2 diabetes. However, pancreatic islets also have alpha cells that produce the hormone glucagon, which acts to raise glucose blood ...

Other cells in the pancreas, called alpha cells, produce glucagon, which increases the amount of glucose that the liver releases into the bloodstream. In type 1 diabetes, the immune system targets ...

FACS-enriched human alpha cells incubated with IL-6 also showed more GLP-1 release compared to control cells (basal GLP-1 release over 0–24 h was 3.1 ± 0.6 nM (mean ± s.e.m.), whereas glucagon ...

Interestingly, alpha cells not only secrete glucagon, but they also express the glucagon receptor, which is itself a GPCR. Thus, glucagon is both secreted by and acts on alpha cells to regulate ...

Most treatments for diabetes focus on insulin, but its counterpart - the hormone glucagon that is produced by alpha cells in the pancreas - has received comparatively little attention, says study ...

Following beta cell loss in mice, 1-2% of glucagon-producing α-cells spontaneously engage in insulin production. In this study, this was increased to 5%, providing new insights on cell flexibility and ...

In groundbreaking diabetes research over the past two decades, Anath Shalev, M.D., has shown that the protein TXNIP regulates survival and function of beta cells, the pancreatic cells that produce the ...

Blocking cell receptors for glucagon, the counter-hormone to insulin, cured mouse models of diabetes by converting glucagon-producing cells into insulin producers instead, a team led by UT ...

Blocking cell receptors for glucagon, the counter-hormone to insulin, cured mouse models of diabetes by converting glucagon-producing cells into insulin producers instead, a team led by UT ...