Proglucagon-derived peptides (PGDPs), including glucagon, GLP-1, and GLP-2, are known to be the key hormones that regulate ...

Proglucagon-derived peptides from the pancreas and gut regulate various aspects of energy homeostasis, with many potential therapeutic applications—glucagon is used to treat hypoglycemia, and ...

Proglucagon-derived peptides are involved in a wide variety of both peripheral as well as central functions, such as glucose homeostasis, gastric emptying, insulin secretion and the regulation of ...

Proglucagon-derived peptides (PGDPs), including glucagon, GLP-1, and GLP-2, are known to regulate lipid metabolism in the liver. However, the mechanism underlying this remains unelucidated.

Proglucagon-derived peptides (PGDPs), including glucagon, GLP-1, and GLP-2, are known to be the key hormones that regulate lipid metabolism in the liver. Derived from the same precursor ...

1) What impact do proglucagon and GIP gene peptide products have on pancreatic beta-cell function? We will assess secretory and functional effects of all peptide products on pancreatic alpha- and beta ...

In the intestine and brain, PC1 converts proglucagon to the incretin hormones, glucagon-like peptide 1 (GLP-1) and glucagon-like peptide 2 (GLP-2). 1,2 . Image Credit: DiBtv/Shutterstock.com.

GCG: Directs the production of Proglucagon, a precursor protein essential for GLP-1 synthesis. PCSK1: Encodes for enzymes that cleave Proglucagon into active GLP-1.

GLP-1, or glucagon-like peptide 1, is a hormone comprising 30 amino acids considered to be created in the intestinal epithelium’s endocrine L cells. These L cells make GLP-1 by the differential ...

Proglucagon-derived peptides (PGDPs), including glucagon, GLP-1, and GLP-2, are known to be the key hormones that regulate lipid metabolism in the liver.