The structure of a neurotransmitter such as dopamine determines ... they show how many molecules bind to the dopamine transporter (DAT). This protein is in charge of recovering dopamine once it has ...

Our bodies have to sense our environment, and receptors are one part of the sensory experience of the body. Receptors, such as those in taste buds... | Cell And Molecular Biology ...

Researchers used advanced microscopy to uncover important protein structures. For the first time, two important protein ...

Semaglutide, a synthetic analog of glucagon-like peptide-1 (GLP-1), has garnered attention for its intriguing properties and potential implications in various r ...

Mechanical stress can strongly influence the capability of a protein to aggregate and the kinetics of aggregation, but there is little insight into the underlying mechanism. Here we study the effect ...

The glucagon-like peptide-1 receptor (GLP-1R) is a key regulator of blood glucose and a prime target for the treatment of type II diabetes and obesity with multiple public drugs. Here we present a ...

They sketched out a made-up 3-D protein — something that did not exist in nature — and asked Rosetta to come up with an amino acid sequence that would fold into that structure. It worked.

Typically, figuring out the structure involves laborious biochemistry to purify the protein, followed by a number of imaging techniques to determine where each of its atoms resides. But in theory ...

Predicting proteins’ structure from their amino acid sequences had stumped researchers since the 1970s. But in 2020, Hassabis and Jumper developed an artificial intelligence model called AlphaFold2.

The AI-powered program AlphaFold2, released in 2021, can predict the three-dimensional structure of any protein from the amino acid sequence encoded in DNA, revolutionizing our understanding of ...

More information: Hakan Doga et al, A Perspective on Protein Structure Prediction Using Quantum Computers, Journal of Chemical Theory and Computation (2024). DOI: 10.1021/acs.jctc.4c00067 ...