New research has identified the enzyme glutamate dehydrogenase 1 (GLUD1) as a new therapeutic target for Duchenne muscular dystrophy (DMD). In preclinical DMD mouse models, investigators demonstrated ...

The brain is one of the body’s most energy-demanding organs, accounting for 2 percent of the body’s weight but consuming 20 ...

Does using Ozempic cause brain fog? It depends on who you ask. This article takes a closer look at what’s going on with ...

The Semaglutide peptide has emerged as a compelling subject in biochemical and physiological research due to its potential ...

Researchers at the Headache Center of the University of Naples "Federico II" gave the glucagon-like peptide-1 (GLP-1 ... pharmacologically targetable pathway." Mild gastrointestinal side effects ...

Adiponectin was then significantly upregulated probably via the gut–brain axis and further activated the AMPK signaling pathway to improve lipid metabolism including the improvement of lipolysis and ...

Furthermore, glucagon signaling was identified as the top-ranked signaling pathway affected in the cardiomyocytes associated with HFpEF. Treatment with a glucagon receptor antagonist significantly ...

Of note, PAX6 replenishment increased the protein expression of those signaling components as well as the insulin‐ and incretin‐induced signaling pathways (Fig 5E–H). Beta cell identity was also ...

We also found that glucagon activates p38α through the protein Epac2 signaling in hepatocytes. This signaling could be another area to investigate for a possible therapeutic intervention.

How Brains Send a Signal That It’s Time to Vomit In a study of mice, researchers worked out a neural pathway that could help researchers alleviate nausea symptoms from chemotherapy drugs.

Switching tracks: Changing the trafficking of the glucagon receptor in the liver regulates its metabolic signaling Helmholtz Munich researchers identify a novel mechanism to modify glucagon ...