Disclosures Diabetes. 2013;62 (2):373-381. Abstract and Introduction Abstract The glucagon-like peptides (GLP-1 and GLP-2) are processed from the proglucagon polypeptide and secreted in equimolar ...

The glucagon-like peptides (GLP-1 and GLP-2) are processed from the proglucagon polypeptide and secreted in equimolar amounts but have opposite effects on chylomicron (CM) production, with GLP-1 ...

Summary and Introduction Summary Oxyntomodulin and peptide tyrosine-tyrosine (PYY) are released from intestinal enteroendocrine cells in response to a meal. These circulating hormones are considered ...

Among the proglucagon-derived peptides, GLP-2 is co-secreted with GLP-1 and exerts an intestinotrophic effect. 39 57 58 GLP-2 enhances intestinal epithelial proliferation and reduces gut permeability, ...

It belongs to the glucagon family of peptides, encoded by the proglucagon gene, that are majorly produced from the enteroendocrine cells of the intestine. The mammalian prohormone, proglucagon, ...

We found previously that in gut endocrine L-cell lines, TCF7L2 controls transcription of the proglucagon gene (gcg), which encodes the incretin hormone glucagon-like peptide-1 (GLP-1). Whereas ...

A common diabetes drug may be the next big thing for migraine relief. In a clinical study, obese patients with chronic migraines who took liraglutide, a GLP-1 receptor agonist, experienced over 50 ...

Proglucagon is cleaved by prohormone convertases 1 and 2 into different breakdown products dependent on the tissue. [14] In the pancreas, glucagon is the primary product.

Long-acting proglucagon-derived peptide (PGDP) therapies have demonstrated additional benefits in cardiovascular, renal, hepatic, and neurological outcomes. 45 Evidence suggests GLP-1RAs may suppress ...

Protein digestion products promote the release of incretins, such as GLP-1, which regulate glucose homeostasis. Our previous studies demonstrated that the egg white peptide fraction stimulates GLP-1 ...

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