Since the delayed hyperglycemic effect of zinc glucagon observed in Case 2 (curve "a", Fig. 3) might be due to plasma-binding proteins for glucagon Dr. Jesse Roth, ...

In contrast, alpha cells secrete glucagon in response to decreased blood glucose levels, and this hormone binds to glucagon receptors in the liver. This binding stimulates breakdown of glycogen ...

"This glucagon receptor structure has opened the door to understanding how hormone peptides bind to this class of receptors, and it will help us solve related receptor structures," Stevens said.

Binding of a specific ligand to the glucagon receptor triggers the release of glucose from the liver during fasting, making this receptor a critical component for maintaining normal glucose ...

Scientists say that α-cell hyperplasia may offer a unique approach to generating new insulin-producing cells.

Glucagon can also play a role in how amino acids (compounds that help make up muscles and tissue in your body) make glucose. And it can break down triglycerides, or fat your body stores, into fuel.

Small-molecule antagonists of glucagon receptor (GCGR), a class B G protein-coupled receptor, reduce plasma glucose levels in patients with type 2 diabetes. Jazayeri et al. now report the 2.5 Å ...

When these same mice were given a human monoclonal antibody called Ab-4 that blocks glucagon binding in the liver, their blood glucose levels normalized and circulating blood levels of insulin were ...

Glucagon receptor structures uncover new arrestin interaction mechanism. Chinese Academy of Sciences Headquarters. Journal Nature DOI 10.1038/s41586-023-06420-x ...

On the other hand, low blood sugar promotes glucagon release, which raises your blood sugar levels. In individuals with diabetes, taking insulin helps decrease and manage your blood sugar after meals.

Upon binding to extracellular agonists, GPCRs stimulate various signaling pathways by recruiting different G proteins (Gs, Gi, Gq, etc.) to mediate a wide variety of physiological functions.