In mouse models of type 1 diabetes, the secretion of glucagon for the counter-regulation of blood sugar levels is restored ...

The research sheds new light on how this enzyme influences glucagon secretion in pancreatic alpha (α) cells, a process crucial for maintaining healthy blood sugar levels. The research ...

Boosting Bacteroides vulgatus in diabetic mice increased GLP-1 secretion, improving blood sugar control and reducing sugar ...

[1] In the presence of elevated glucose concentrations, GLP-1 and GIP increase insulin release and GLP-1 lowers glucagon secretion, thereby modulating the postmeal rise in glucose concentration ...

In addition to impaired insulin secretion, type 2 diabetic patients also have elevated levels of glucagon, which worsens hyperglycemia by increasing glucose production by the liver. Type 2 ...

“Fasting or high energy–consumption sports activities can result in low plasma glucose concentrations and in response, glucagon secretion is stimulated to promote endogenous glucose production ...

Several DPP-4 inhibitors are in clinical development; these are orally active and increase levels of active GLP-1, which in turn increases insulin secretion and reduces glucagon secretion and ...

“Of central importance for a novel T2D drug is that it targets the key islet dysfunctions that underlie hyperglycaemia — that is, impaired insulin secretion, inappropriately high glucagon ...