News

Medscape7d
GLP-1 and GLP-2 and Intestinal Lipoprotein Production - Medscape Drugs & Diseases
Abstract and Introduction Abstract. The glucagon-like peptides (GLP-1 and GLP-2) are processed from the proglucagon polypeptide and secreted in equimolar amounts but have opposite effects on ...
Medscape7d
GLP-1 and GLP-2 and Intestinal Lipoprotein Production - Medscape
The glucagon-like peptides (GLP-1 and GLP-2) are processed from the proglucagon polypeptide and secreted in equimolar amounts but have opposite effects on chylomicron (CM) production, with GLP-1 ...
Medscape9d
The Role of Oxyntomodulin and PYY in Appetite Control
Authors and Disclosures. Katie Wynne is a Wellcome Trust Clinical Research Fellow and Specialist Registrar in Endocrinology, Diabetes and Internal Medicine in the Department of Metabolic Medicine, ...
gut.bmj9d
Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability | Gut
Prebiotic increased the endogenous intestinotrophic proglucagon-derived peptide (GLP-2) production whereas the GLP-2 antagonist abolished most of the prebiotic effects. Finally, pharmacological GLP-2 ...
Frontiers9d
Frontiers | GLP-2 regulation of intestinal lipid handling
It belongs to the glucagon family of peptides, encoded by the proglucagon gene, that are majorly produced from the enteroendocrine cells of the intestine. The mammalian prohormone, proglucagon, ...
archive3d
The Wnt Signaling Pathway Effector TCF7L2 Controls Gut and Brain Proglucagon Gene Expression and Glucose Homeostasis.
This article is from Diabetes, volume 62.AbstractThe type 2 diabetes risk gene TCF7L2 is the effector of the Wnt signaling pathway. We found previously that in ...
Science Daily12d
Diabetes drug cuts migraines in half by targeting brain pressure
Proglucagon-derived peptides (PGDPs), including glucagon, GLP-1, and GLP-2, are known to regulate lipid metabolism in the liver. However, the ...
The Lancet21d
Mazdutide, a dual agonist targeting GLP-1R and GCGR, mitigates diabetes-associated cognitive dysfunction: mechanistic insights from multi-omics analysis - eBioMedicine - The Lancet
Long-acting proglucagon-derived peptide (PGDP) therapies have demonstrated additional benefits in cardiovascular, renal, hepatic, and neurological outcomes. 45 Evidence suggests GLP-1RAs may suppress ...
C&EN14d
A Lysozyme-Derived Peptide Induces GLP-1 Secretion in Mouse Jejunal Organoids and Modulates Glycemia in Rats | Journal of Agricultural and Food Chemistry - ACS Publications
Protein digestion products promote the release of incretins, such as GLP-1, which regulate glucose homeostasis. Our previous studies demonstrated that the egg white peptide fraction stimulates GLP-1 ...
Science Daily4d
Cholesterol News -- ScienceDaily
Proglucagon-derived peptides (PGDPs), including glucagon, GLP-1, and GLP-2, are known to regulate lipid metabolism in the liver. However, the ...
gut.bmj7d
Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism | Gut
Objectives Gut microbiota is a key component in obesity and type 2 diabetes, yet mechanisms and metabolites central to this interaction remain unclear. We examined the human gut microbiome’s ...